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Answer:

We have spotted ISLE (4 Letters) a total of 391 times in our database. Below you may see the clues associated with ISLE and also when and where was it last seen:

Definition

See Aisle.
An island.
A spot within another of a different color, as upon the wings of some insects.
To cause to become an island, or like an island; to surround or encompass; to island.

Referring crossword puzzle clues

Usage among publishers: