Answer: 
	
We have spotted SIS (3 Letters) a total of 788 times in our database. Below you may see the clues associated with SIS and also when and where was it last seen:
	
		
			Definition
			
				
											
															| • | A colloquial abbreviation of Sister. | 
											
															| • | Six. See Sise. | 
									
			
		 
	 
	Referring crossword puzzle clues
Usage among publishers:
- LA Times: Oct 25, 2025
- USA Today: Oct 14, 2025
- LA Times: Sep 28, 2025
- Universal: Sep 23, 2025
- LA Times: Sep 10, 2025
- Thomas Joseph: Sep 6, 2025
- LA Times: Sep 4, 2025
- USA Today: Aug 31, 2025
- LA Times: Aug 25, 2025
- Universal: Aug 19, 2025
- LA Times: Aug 17, 2025
- Newsday: Aug 14, 2025
- Universal: Aug 10, 2025
- Universal: Aug 1, 2025
- Newsday: Jul 19, 2025
- Newsday: Jul 9, 2025
- USA Today: Jul 6, 2025
- USA Today: Jun 28, 2025
- USA Today: Jun 21, 2025
- USA Today: Jun 7, 2025
- USA Today: May 5, 2025
- LA Times: Mar 27, 2025
- LA Times: Mar 16, 2025
- Thomas Joseph: Mar 12, 2025
- Wall Street Journal: Mar 4, 2025
- Newsday: Feb 25, 2025
- Universal: Feb 18, 2025
- Universal: Feb 7, 2025
- USA Today: Feb 6, 2025
- New York Times: Jan 19, 2025